Anxiety and Depression in Pre-Operative Patients in Faisalabad Institute of Cardiology: A Cross-Sectional Study
DOI:
https://doi.org/10.62497/irjcs.177Keywords:
Preoperative Care, Anxiety, Depression, Cardiac Surgical Procedures, Heart Disease, Disorder, Cardiovascular Disease, Psychological Stress, Adult, Risk FactorsAbstract
Background: Pre-operative patients frequently suffer from depression and anxiety, which can negatively influence their general health and potentially affect surgical outcomes. Symptoms of depression and anxiety are present in a considerable number of individuals prior to surgery. The prevalence rates vary depending on the type of surgery, patient characteristics, and underlying medical conditions.
Objective: The present study aimed to assess preoperative anxiety and depression among patients undergoing heart surgery at the Faisalabad Institute of Cardiology (FIC), Pakistan, and to identify patient-related factors associated with anxiety levels.
Methods: This study was conducted from June 2024 to March 2025 in the Microbiology Research Laboratory (MRL), Department of Pathology, Pakistan Institute of Medical Sciences (PIMS), Islamabad, and at the Faisalabad Institute of Cardiology. A representative sample of preoperative heart surgery patients was selected from the FIC preoperative evaluation clinics and wards. The sample size was calculated based on the expected prevalence of anxiety and depression and the desired level of accuracy, resulting in a sample of 100 patients. Standardized questionnaires were used to assess anxiety and depression, and their internal consistency was evaluated using Cronbach’s alpha.
Results: The distribution of subjects among the 55 adult patients analyzed was balanced. The questionnaires demonstrated strong internal consistency, with Cronbach’s alpha values of 0.85 and 0.93. Significant differences were observed between patients with high trait anxiety and those with normal anxiety levels regarding situational anxiety scores (p < 0.05). Female sex was the only patient-related factor significantly associated with higher anxiety levels (p < 0.05). Further stratification revealed that younger women and females with prior experience of general anesthesia reported higher anxiety levels compared to their male counterparts.
Conclusion: The study identified several patient-related factors influencing preoperative anxiety and demonstrated findings consistent with the validated Korean versions of the anxiety assessment surveys. A notable sex-related difference in anxiety regarding future events was observed, which may be explained by a combination of biological and psychological factors. These findings highlight the importance of recognizing and addressing anxiety in preoperative cardiac surgery patients, particularly among female patients.
References
Nabi S, Ali S, Khan AZ, Khan MN, Kumari G. Anemia and bone marrow suppression after intra-arterial chemotherapy in children with retinoblastoma. Pakistan Journal of Medical & Health Sciences. 2025 May 5;19(4):13-8. DOI: https://doi.org/10.53350/pjmhs02025194.4.
Acoba EF. Social support and mental health: the mediating role of perceived stress. Front Psychol. 2024 Feb 21;15:1330720. doi: 10.3389/fpsyg.2024.1330720.
Palese A, Cecconi M, Moreale R, Skrap M. Pre-operative stress, anxiety, depression and coping strategies adopted by patients experiencing their first or recurrent brain neoplasm: an explorative study. Stress Health. 2012;28(5):416-25.
Ahmad S, Hussain S, Ali S, Shah WA, Riaz A, Qazi SA, et al. Infectious causes of acute meningoencephalitis syndrome in children: Insights from a tertiary care hospital in Pakistan. Mathews J Pediatr. 2025;10(1):1-11. DOI: https://doi.org/10.30654/MJP.10038
Abend R. Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum. Neurosci Biobehav Rev. 2023 Sep;152:105305. doi: 10.1016/j.neubiorev.2023.105305.
Rai P, Ramchandani KJ, Ali A, Hamid M, Ali S, Rasool MS, et al. Knowledge and practices on the prevention and management of diarrhea in children under-5 years in Pakistan. Natl J Med Health Sci. 2024;6(1):9-15.
Rehman Z, Hamid M, Khan A, Gul S, Ali S, Ahmad I, et al. Frequency of clinical syndromes in children with congenital heart defects admitted at tertiary care hospital. Biol Clin Sci Res J. 2024;2024:1026.
Ibrahim M, Hussain F, Ali S, Ahmad J, Naseem M, Atta L. Frequency of urinary tract infection in neonates with jaundice. Res Med Sci Rev. 2025;3(2). Available from: https://medscireview.net/index.php/Journal/article/view/644
Iqbal A, Muhammad R, Khan BB, Jamshed A, Rehman MI, et al. Comparative study of C-reactive protein and complete blood count in cancer and non-cancer patients followed by antibiogram analysis of isolated bacterial pathogens. J Bacteriol Mycol Open Access. 2023;11(1):1-4.
Ramesh C, Nayak BS, Pai VB, George A, George LS, Devi ES. Pre-operative anxiety in patients undergoing coronary artery bypass graft surgery: a cross-sectional study. Int J Afr Nurs Sci. 2017;7:31-6.
Ali S, Rubab TE, Mushtaq W. Investigating the role of early nutritional interventions in shaping long-term pediatric health outcomes: a multidisciplinary approach to growth and development. J Health Wellness Community Res. 2025:e136. DOI: https://doi.org/10.61919/7han6v98
Iqbal A, Mehboob Z, Haq I. Assessment of current medical management approaches for thyroid nodules and cancer in a tertiary care setting. Innov Res Appl Biol Chem Sci. 2024;2(2):199-204. DOI: https://doi.org/10.62497/IRABCS.2024.78
Ali S, Shah MA, Khan MH, Shah ZA, Waheed A, Ahmad A, et al. Duchenne muscular dystrophy: an atypical adult presentation and comprehensive literature review with management recommendations. Biotechnol J Int. 2025;29(3):28-60. DOI: 10.9734/bji/2025/v29i3776
Rubab TE, Ali S, Kumar S, Batool R. Evaluating the effectiveness of current asthma management protocols in pediatric populations: a longitudinal study on symptom control and quality of life. Res Med Sci Rev. 2025;3(4):682-8. Available from: https://medscireview.net/index.php/Journal/article/view/996
Ali S, Raza MA, Fazal S, Ahmad RT, Fatima M, Shahid A, et al. Exploring the association between passive exposure to household smoking and frequency of recurrent wheezing in children. J Health Wellness Community Res. 2025:e308. https://jhwcr.com/index.php/jhwcr/article/view/308
Jones AR, Al-Naseer S, Bodger O, James ETR, Davies AP. Does pre-operative anxiety and/or depression affect patient outcome after primary knee replacement arthroplasty? Knee. 2018;25(6):1238-46.
Iqbal A, Ahmed A, Rehman S, Ali R. Impact of long-term aspirin use on cardiovascular disease prevention and bleeding risks. Innov Res Appl Biol Chem Sci. 2024;2(2):193-8.
Kang HJ, Kim BH. A study on stress, anxiety, and depression of pre-operational patients. J Korean Acad Adult Nurs. 1999;11(4):809-19.
Ng SK, Chau AW, Leung WK. The effect of pre-operative information in relieving anxiety in oral surgery patients. Community Dent Oral Epidemiol. 2004;32(3):227-35.
Seagrave KG, Lewin AM, Harris IA, Badge H, Naylor J. Association between pre-operative anxiety and/or depression and outcomes following total hip or knee arthroplasty. J Orthop Surg. 2021;29(1):2309499021992605.
Iqbal A, Rehman S, Haq I. Prevalence and risk factors of ENT symptoms in extra-pulmonary tuberculosis patients. Innov Res Appl Biol Chem Sci. 2024;2(2):242-7.
Alattas SA, Smith T, Bhatti M, Wilson-Nunn D, Donell S. Greater pre-operative anxiety, pain and poorer function predict a worse outcome of a total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2017;25(11):3403-10.
Zeb A, Hammad AM, Baig R, Rahman S. Pre-operative anxiety in patients at tertiary care hospital, Peshawar, Pakistan. J Clin Trials Res. 2019;2:76-80.
Farhan M, Faisal M. The potential role of polyphenol supplementation in preventing and managing depression: a review of current research. Life. 2024;14(10):1342.
McLean CP, Asnaani A, Litz BT, Hofmann SG. Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res. 2011;45(8):1027-35.
Lim NC, Fan CH, Yong MK, Wong EP, Yip LW. Assessment of depression, anxiety, and quality of life in Singaporean patients with glaucoma. J Glaucoma. 2016;25(7):605-12.
Bahram M, Gaballa G. The value of pre-operative magnetic resonance cholangiopancreatography in management of patients with gall stones. Int J Surg. 2010;8(5):342-5.
Woldegerima YB, Fitwi GL, Yimer HT, Hailekiros AG. Prevalence and factors associated with preoperative anxiety among elective surgical patients at University of Gondar Hospital, Northwest Ethiopia: a cross-sectional study. Int J Surg Open. 2017;10:21-9.
Erkilic E, Kesimci E, Soykut C, Doger C, Gumus T, Kanbak O. Factors associated with preoperative anxiety levels of Turkish surgical patients from a single center in Ankara. Patient Prefer Adherence. 2017;11:291-6. doi:10.2147/PPA.S127342.
Kvaal K, Ulstein I, Nordhus IH, Engedal K. The Spielberger State-Trait Anxiety Inventory (STAI): the State Scale in detecting mental disorders in geriatric patients. Int J Geriatr Psychiatry. 2005;20(7):629-34.
Haq FU, Siraj A, Ameer MA, Hamid T, Rahman M, Khan S, et al. Comparative review of drugs used in diabetes mellitus—new and old. J Diabetes Mellit. 2021;11(4):115-31.
Levett DZH, Grimmett C. Psychological factors, prehabilitation and surgical outcomes: evidence and future directions. Anaesthesia. 2019;74(Suppl 1):36-42.
Misal US, Joshi SA, Shaikh MM. Delayed recovery from anesthesia: A postgraduate educational review. Anesth Essays Res. 2016 May-Aug;10(2):164-72. doi: 10.4103/0259-1162.165506.
Ullah I, Khan AA, Iqbal J, Ali S, Siddiqui SK, Ali S, Ihsan H. Comparison of azithromycin and amoxicillin in the management of pediatric community-acquired pneumonia. Journal of Population Therapeutics and Clinical Pharmacology. 2024;31(8):3398-404. https://jptcp.com/index.php/jptcp/article/view/9317
Additional Files
Published
Issue
Section
License
Copyright (c) 2025 Muhammad Adnan, Adnan Gill, Atta Ur Rehman, Muhammad Iqbal Khan Rahman, Nasir Anwar, Sayed Ali, Salman Khan (Author)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.